University of South Alabama

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Novel Heart Attack Therapy: Caspase Inhibition Prior to Repurfusion
OPPORTUNITY Preventing heart muscle death (infarction) during a heart attack is an important goal of treatment. To this end, patients typically receive platelet inhibitors and early opening of the thrombosed artery (reperfusion), both of which aim to reduce heart muscle loss. This treatment has lowered, but not eliminated, mortality and morbidity i...
Inventor(s): Jonathon Audia, James Downey, Diego Alvarez, Michael Cohen
Category(s): Therapeutics, All Technologies
Multi-Well Plate System to Assess Cellular Mechanobiology
OPPORTUNITY In a sheet of endothelial cells, the cellular response to physical and chemical stimuli is often regulated uniquely by the mechanical microenvironment of the cell. However, the mechanical microenvironment which is composed of mechanical stretch, fluid pressure and shear stress, is not static. Monolayer stress microscopy (MSM) has enable...
Inventor(s): Dhananjay Tambe, Neel Patel
Category(s): Engineering Device or Method, Research Tools, All Technologies
Platform DNA Vaccine
OPPORTUNITY The global market for DNA vaccines is expected to grow to $2.7 billion by 2019, with a five-year compound annual growth rate (GAGR) of 54.8%. The clinical vaccines category, the largest and fastest-growing segment of this market, is surging at 81.2% CAGR. Human clinical DNA vaccines represent the primary future market opportunity for th...
Inventor(s): Brian Fouty, Victor Solodushko, Vira Bitko
Category(s): Anti-Viral Therapeutics, Vaccines, All Technologies
Leads to Assess Accurate Neonate Heart Rate in the Delivery Room
OPPORTUNITY Ten percent (10%) of births require some form of neonate resuscitation. Heart rate (HR) is the most important clinical indicator to evaluate the status of a newborn, and it is also used to guide resuscitation efforts. Immediately after birth, the infant’s HR must be assessed as accurately and quickly as possible to determine if an...
Inventor(s): Om Jha, Gabriel Eyal
Category(s): Medical Device or Method, All Technologies
Methods for Establishing Mammalian Cell Lines with Altered Mitochondrial DNA Copy Number
OPPORTUNITY Reduced mitochondria DNA (mtDNA) copy number is associated with mitochondrial disease, which is incurable, progressive, and often fatal in early childhood. Currently, unavailability of an effective means to manipulate mtDNA copy number in cells slows progress in our understanding of the mechanisms by which mtDNA deletion contributes to ...
Inventor(s): Mikhail Alexeyev, Domenic Spadafora
Category(s): Cell Line, Research Tools, All Technologies
Nanoparticles as Skin Cancer Chemopreventive Agents
OPPORTUNITY Sunscreens are considered an over-the-counter drug and are regulated by the FDA. Sunscreen is used for the protection of UV radiation contained in sunlight. Over the past several years, awareness of skin cancers caused by sunlight has increased, and more attention is being paid to the importance of sunscreen and how it works. The Americ...
Inventor(s): Ajay Singh, Seema Singh, Sumit Arora
Category(s): Cancer Therapeutics, Personal Care & Cosmetics, All Technologies
Expression of Merlin Protein as a Predictive Marker for Breast Cancer Diagnosis
OPPORTUNITY The American Cancer Society’s estimates for breast cancer in the United States in 2017 that about 253,000 new cases of invasive breast cancer will be diagnosed in women. About 63,000 new cases of carcinoma in situ (CIS) will be diagnosed (CIS is noninvasive and is the earliest form of breast cancer), and about 41,000 women will di...
Inventor(s): Lalita Shevde-Samant, Rajeev Samant, Madhuri Mulekar, J. Allan Tucker
Category(s): Cancer Therapeutics, Biomarkers, Screening Tests, All Technologies
Balloon Sealed Device to Instill Contrast into Penetrating Traumatic Wounds for Radiographic Diagnosis of Injury
OPPORTUNITY Bodily injuries can be loosely categorized as either blunt or penetrating wounds. When medical personnel deal with a penetrating wound there is a time consuming, and often invasive, diagnostic process to determine the next steps to address any internal damage. The need for this invasive diagnostic process is due to the nature of penetra...
Inventor(s): Patrick Bosarge
Category(s): Medical Device or Method, All Technologies
Reversible Carbon Capture and Sequestration
OPPORTUNITY Global CO2 emissions from energy-related industries are expected to rise from 27 gigatons in 2005 to 42 gigatons in 2030. There is hence a clear need for efficient and cost effective CO2 scrubbing systems and an indication that demand for such systems will increase over the coming decades. Carbon capture and sequestration is seen as cri...
Inventor(s): James Davis
Category(s): Environmental Monitoring & Resiliency, Ionic Liquids, All Technologies
Boronium-Ion-Based Ionic Liquids for Use in Batteries
OPPORTUNITY Unlike conventional molten salts (for example, molten sodium chloride), ionic liquids often melt below 100 °C. When an ionic liquid has a melting point below room temperature, it is said to be a room-temperature ionic liquid. Since their melting points are low, room-temperature ionic liquids can act as reaction solvents. Room-temper...
Inventor(s): James Davis
Category(s): Ionic Liquids, Environmental Monitoring & Resiliency, All Technologies
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