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Search Results - biomarkers

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Regulation of Osteopontin Using Hedgehog Pathway
OPPORTUNITY The role of developmental pathways such as the Hedgehog pathway has been studied for its involvement in several malignancies. The Hedgehog pathway activates signaling in cancer cells that causes them to proliferate, survive and be more aggressive. The Hedgehog pathway can be inhibited by small molecule inhibitors. Several of these inhibitors...
Inventor(s): Rajeev Samant, Lalita Shevde-Samant, Shamik Das
Category(s): Biomarkers, Cancer Therapeutics, All Technologies
Expression of Merlin Protein as a Predictive Marker for Breast Cancer Diagnosis
OPPORTUNITY The American Cancer Society’s estimates for breast cancer in the United States in 2017 that about 253,000 new cases of invasive breast cancer will be diagnosed in women. About 63,000 new cases of carcinoma in situ (CIS) will be diagnosed (CIS is noninvasive and is the earliest form of breast cancer), and about 41,000 women will die...
Inventor(s): Lalita Shevde-Samant, Rajeev Samant, Madhuri Mulekar, J. Allan Tucker
Category(s): Cancer Therapeutics, Biomarkers, Screening Tests, All Technologies
Diagnosis of intellectual disability and developmental delay
OPPORTUNITY The overall understanding of the molecular etiologies of intellectual disability (ID) and developmental delay (DD) is increasing with next-generation sequencing technologies identifying genetic variants in patients with these disorders. However, detailed analyses conclusively confirming variants, as well as the underlying molecular mechanisms...
Inventor(s): Erin Ahn, Jung-Hyun Kim, Ssang-Taek Lim
Category(s): Biomarkers, Screening Tests, All Technologies
SON Isoform Ratio for Acute Myeloid Leukemia Diagnosis
OPPORTUNITYAcute myeloid leukemia is a cancer of the blood, bone marrow and other tissues. Although treatment for acute myeloid leukemia has improved, it is only curable in 35-40% of people 60 years old or younger and in 5-15% of patients over the age of 60. Median survival of patients that do not receive intensive chemotherapy is only 5-10 months....
Inventor(s): Erin Ahn, Jung-Hyun Kim, Ssang-Taek Lim
Category(s): Biomarkers, Screening Tests, All Technologies
XRCC1 as a Predictive Biomarker for Radiation Responsiveness in Patients with Prostate Cancer
OPPORTUNITY According to statistics from the American Cancer Society, prostate cancer is the second most common cancer in American men, next to skin cancer. In 2018, it is estimated that 164,690 people will be diagnosed and about 29,430 people will die of prostate cancer. About 1 man in 9 will be diagnosed with prostate cancer during his lifetime....
Inventor(s): Eddie Reed
Category(s): Biomarkers, Cancer Therapeutics, Screening Tests, All Technologies
Methods and Compositions for Ameliorating Pancreatic Cancer
OPPORTUNITY According to statistics from the American Cancer Society, in the United States, an estimated 54,000 (28,000 men and 26,000 women) will be diagnosed and about 43,000 people (22,000 men and 21,000 women) will die of pancreatic cancer in 2017. Pancreatic cancer accounts for about 3% of all cancers in the Unite States and about 7% of all cancer...
Inventor(s): Ajay Singh, Seema Singh
Category(s): Biomarkers, Cancer Therapeutics, Screening Tests, All Technologies
c-Myb Inhibition for Treatment of Prostate Cancer via RNA Therapeutics
OPPORTUNITY Prostate cancer is the most frequently diagnosed cancer in men and is an extremely heterogeneous disease, indicating that multiple genes can cause or contribute to the condition. In 2018, it is estimated that 164,690 people will be diagnosed and about 29,430 people will die of prostate cancer. About 1 man in 9 will be diagnosed with prostate...
Inventor(s): Ajay Singh, Seema Singh, Sanjeev Srivastava
Category(s): Biomarkers, Cancer Therapeutics, All Technologies