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Search Results - rajeev+samant

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Regulation of Osteopontin Using Hedgehog Pathway
OPPORTUNITY The role of developmental pathways such as the Hedgehog pathway has been studied for its involvement in several malignancies. The Hedgehog pathway activates signaling in cancer cells that causes them to proliferate, survive and be more aggressive. The Hedgehog pathway can be inhibited by small molecule inhibitors. Several of these inhibitors...
Inventor(s): Rajeev Samant, Lalita Shevde-Samant, Shamik Das
Category(s): Biomarkers, Cancer Therapeutics, All Technologies
Expression of Merlin Protein as a Predictive Marker for Breast Cancer Diagnosis
OPPORTUNITY The American Cancer Society’s estimates for breast cancer in the United States in 2017 that about 253,000 new cases of invasive breast cancer will be diagnosed in women. About 63,000 new cases of carcinoma in situ (CIS) will be diagnosed (CIS is noninvasive and is the earliest form of breast cancer), and about 41,000 women will die...
Inventor(s): Lalita Shevde-Samant, Rajeev Samant, Madhuri Mulekar, J. Allan Tucker
Category(s): Cancer Therapeutics, Biomarkers, Screening Tests, All Technologies
Inhibition of Gli1 Increases Sensitivity to Cisplatin
OPPORTUNITY Platinum-based anticancer agents are among the most widely used agents in clinical oncology. Nucleotide excision repair (NER) is the pathway through which platinum–DNA damage is repaired and, ERCC1 is a useful biomarker for the NER process in human cells. Understanding the molecular and pharmacological control of NER may allow for...
Inventor(s): Eddie Reed, Rajeev Samant
Category(s): Cancer Therapeutics, DNA Repair Therapeutics, All Technologies