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Inhibition of Gli1 Increases Sensitivity to Cisplatin
OPPORTUNITY Platinum-based anticancer agents are among the most widely used agents in clinical oncology. Nucleotide excision repair (NER) is the pathway through which platinum–DNA damage is repaired and, ERCC1 is a useful biomarker for the NER process in human cells. Understanding the molecular and pharmacological control of NER may allow for...
Inventor(s): Eddie Reed, Rajeev Samant
Category(s): Cancer Therapeutics, DNA Repair Therapeutics, All Technologies