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Methods for Establishing Mammalian Cell Lines with Altered Mitochondrial DNA Copy Number
OPPORTUNITY Reduced mitochondria DNA (mtDNA) copy number is associated with mitochondrial disease, which is incurable, progressive, and often fatal in early childhood. Currently, unavailability of an effective means to manipulate mtDNA copy number in cells slows progress in our understanding of the mechanisms by which mtDNA deletion contributes to cellular...
Inventor(s): Mikhail Alexeyev, Domenic Spadafora
Category(s): Cell Line, Research Tools, All Technologies