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Search Results - Research+Tools

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Accurate Tracking and Measurement of Intercellular Mitochondrial Transfer
Opportunity Mitochondria are commonly referred to as the powerhouse of the cell, and any change in mitochondrial function can drastically alter normal cell function. Diseases including neurodegeneration and cancer have been linked to changes in mitochondrial transfer between cells, which can weaken the functioning of healthy cells. Although studying...
Inventor(s): Simon Grelet, Greg Hoover
Category(s): All Technologies, Cancer Therapeutics, Research Tools, Screening Tests
Clinical Measurement of Circulating Extracellular Vesicles in Cancer Diagnosis, Prognosis, and Treatment Response
Opportunity With vague-presenting early symptoms and a 5-year survival rate of around 10% in the USA, pancreatic cancer (PC) is difficult to diagnose early and has limited effective therapeutic options. However, if detected earlier, PC survival increases to 80%, suggesting that early detection is key to enhancing survival. Carbohydrate antigen 19-9,...
Inventor(s): Santanu Dasgupta, Ajay Singh, Kunwar Vikramdeo
Category(s): All Technologies, Screening Tests, Research Tools
Multi-Well Plate System to Assess Cellular Mechanobiology
OPPORTUNITY In a sheet of endothelial cells, the cellular response to physical and chemical stimuli is often regulated uniquely by the mechanical microenvironment of the cell. However, the mechanical microenvironment which is composed of mechanical stretch, fluid pressure and shear stress, is not static. Monolayer stress microscopy (MSM) has enabled...
Inventor(s): Dhananjay Tambe, Neel Patel
Category(s): Engineering Device or Method, Research Tools, All Technologies
Methods for Establishing Mammalian Cell Lines with Altered Mitochondrial DNA Copy Number
OPPORTUNITY Reduced mitochondria DNA (mtDNA) copy number is associated with mitochondrial disease, which is incurable, progressive, and often fatal in early childhood. Currently, unavailability of an effective means to manipulate mtDNA copy number in cells slows progress in our understanding of the mechanisms by which mtDNA deletion contributes to cellular...
Inventor(s): Mikhail Alexeyev, Domenic Spadafora
Category(s): Cell Line, Research Tools, All Technologies
Biosynthesis of Silver Nanoparticles Using Plant Extracts
OPPORTUNITY The emergence of nanosilver materials in anti-microbial consumer goods and medical products is a major growth driver in the nanosilver market; a growth that is expected to continue from US$1.1 billion in 2015 to around US$2.45 billion by 2022. To meet these needs, more than five hundred tons of silver nanoparticles (AgNP) are synthesized...
Inventor(s): Sumit Arora, Om Jha, Zohaib Ijaz, Yousef Omar
Category(s): All Technologies, Engineering Device or Method, Research Tools
Modified Media for Enhanced Mouse Primary Cell Culture
OPPORTUNITY Pulmonary endothelium (PE) provide vital functions in the lung and play important roles in inflammation, hemostasis, angiogenesis and regulation of vascular tone. The PE also exhibit therapeutic potential in a variety of areas such as gene therapy, cardiac regeneration, vascular graft potential, and tissue transplants. Given the importance...
Inventor(s): Anna Buford
Category(s): All Technologies, Research Tools