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Methods for Establishing Mammalian Cell Lines with Altered Mitochondrial DNA Copy Number
OPPORTUNITY Reduced mitochondria DNA (mtDNA) copy number is associated with mitochondrial disease, which is incurable, progressive, and often fatal in early childhood. Currently, unavailability of an effective means to manipulate mtDNA copy number in cells slows progress in our understanding of the mechanisms by which mtDNA deletion contributes to ...
Inventor(s): Mikhail Alexeyev, Domenic Spadafora
Category(s): Cell Line, Research Tools, All Technologies
Nanoparticles as Skin Cancer Chemopreventive Agents
OPPORTUNITY Sunscreens are considered an over-the-counter drug and are regulated by the FDA. Sunscreen is used for the protection of UV radiation contained in sunlight. Over the past several years, awareness of skin cancers caused by sunlight has increased, and more attention is being paid to the importance of sunscreen and how it works. The Americ...
Inventor(s): Ajay Singh, Seema Singh, Sumit Arora
Category(s): Cancer Therapeutics, Personal Care & Cosmetics, All Technologies
Expression of Merlin Protein as a Predictive Marker for Breast Cancer Diagnosis
OPPORTUNITY The American Cancer Society’s estimates for breast cancer in the United States in 2017 that about 253,000 new cases of invasive breast cancer will be diagnosed in women. About 63,000 new cases of carcinoma in situ (CIS) will be diagnosed (CIS is noninvasive and is the earliest form of breast cancer), and about 41,000 women will di...
Inventor(s): Lalita Shevde-Samant, Rajeev Samant, Madhuri Mulekar, J. Allan Tucker
Category(s): Cancer Therapeutics, Biomarkers, Screening Tests, All Technologies
Balloon Sealed Device to Instill Contrast into Penetrating Traumatic Wounds for Radiographic Diagnosis of Injury
OPPORTUNITY Bodily injuries can be loosely categorized as either blunt or penetrating wounds. When medical personnel deal with a penetrating wound there is a time consuming, and often invasive, diagnostic process to determine the next steps to address any internal damage. The need for this invasive diagnostic process is due to the nature of penetra...
Inventor(s): Patrick Bosarge
Category(s): Medical Device or Method, All Technologies
Reversible Carbon Capture and Sequestration
OPPORTUNITY Global CO2 emissions from energy-related industries are expected to rise from 27 gigatons in 2005 to 42 gigatons in 2030. There is hence a clear need for efficient and cost effective CO2 scrubbing systems and an indication that demand for such systems will increase over the coming decades. Carbon capture and sequestration is seen as cri...
Inventor(s): James Davis
Category(s): Environmental Monitoring & Resiliency, Ionic Liquids, All Technologies
Boronium-Ion-Based Ionic Liquids for Use in Batteries
OPPORTUNITY Unlike conventional molten salts (for example, molten sodium chloride), ionic liquids often melt below 100 °C. When an ionic liquid has a melting point below room temperature, it is said to be a room-temperature ionic liquid. Since their melting points are low, room-temperature ionic liquids can act as reaction solvents. Room-temper...
Inventor(s): James Davis
Category(s): Ionic Liquids, Environmental Monitoring & Resiliency, All Technologies
Diagnosis of intellectual disability and developmental delay
OPPORTUNITY The overall understanding of the molecular etiologies of intellectual disability (ID) and developmental delay (DD) is increasing with next-generation sequencing technologies identifying genetic variants in patients with these disorders. However, detailed analyses conclusively confirming variants, as well as the underlying molecular mech...
Inventor(s): Erin Ahn, Jung-Hyun Kim, Ssang-Taek Lim
Category(s): Biomarkers, Screening Tests, All Technologies
SON Isoform Ratio for Acute Myeloid Leukemia Diagnosis
OPPORTUNITYAcute myeloid leukemia is a cancer of the blood, bone marrow and other tissues. Although treatment for acute myeloid leukemia has improved, it is only curable in 35-40% of people 60 years old or younger and in 5-15% of patients over the age of 60. Median survival of patients that do not receive intensive chemotherapy is only 5-10 months....
Inventor(s): Erin Ahn, Jung-Hyun Kim, Ssang-Taek Lim
Category(s): Biomarkers, Screening Tests, All Technologies
Biosynthesis of Silver Nanoparticles Using Plant Extracts
OPPORTUNITY The emergence of nanosilver materials in anti-microbial consumer goods and medical products is a major growth driver in the nanosilver market; a growth that is expected to continue from US$1.1 billion in 2015 to around US$2.45 billion by 2022. To meet these needs, more than five hundred tons of silver nanoparticles (AgNP) are synthesize...
Inventor(s): Sumit Arora, Om Jha, Zohaib Ijaz, Yousef Omar
Category(s): All Technologies, Engineering Device or Method, Research Tools
Modified Media for Enhanced Mouse Primary Cell Culture
OPPORTUNITY Pulmonary endothelium (PE) provide vital functions in the lung and play important roles in inflammation, hemostasis, angiogenesis and regulation of vascular tone. The PE also exhibit therapeutic potential in a variety of areas such as gene therapy, cardiac regeneration, vascular graft potential, and tissue transplants. Given the importa...
Inventor(s): Anna Buford
Category(s): All Technologies, Research Tools
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